Panama Airfares On Sale - from just US$316* roundtrip from Grand Cayman

Fly nonstop from Grand Cayman to Panama with airfares on sale from just US$316* roundtrip, including taxes & fees!

*Base fare:

US$170

*Government and airport taxes and fees

US$145.42

*Restrictions

The quoted fare is based on roundtrip economy class purchase for travel from Grand Cayman to Panama and includes government and airport taxes and fees of up to US$145.42. Tickets must be issued within one day of booking or by August 08, 2026, whichever is earlier.  Fares are valid for travel September 08 through December 12, 2026.  All segments must be confirmed. This fare is not available From Panama October 19 through October 23, November 09, and November 30, 2026, to Panama October 15 through October 19, November 05, and November 26, 2026.  Fares are non-refundable and non-transferable. Seats are limited for this fare and may not be available on every flight. Change fee is US$75.00 plus any fare difference. Through fares to the Sister Islands are available for an additional US$62.20 per roundtrip. In case of no show, ticket has no value.

*Booking period

July 31, 2026 - August 8, 2026

Travel period:

September 8, 2026 through December 12, 2026

*Blackout dates

From Panama: October 19-23, 2026; November 9, 2026; November 30, 2026

To Panama: October 15-19, 2026; November 5, 2026; November 26, 2026

For travel originating in Panama, the airfare is US$328* roundtrip including taxes & fees. The following conditions apply: 

The quoted fare is based on roundtrip economy class purchase for travel from Panama to Grand Cayman and includes government and airport taxes and fees of up to US$157.32. Tickets must be issued within one day of booking or by August 08, 2026, whichever is earlier.  Fares are valid for travel September 08 through December 12, 2026.  All segments must be confirmed. This fare is not available From Panama October 19 through October 23, November 09, and November 30, 2026, to Panama October 15 through October 19, November 05, and November 26, 2026.  Fares are non-refundable and non-transferable. Seats are limited for this fare and may not be available on every flight. Change fee is US$75.00 plus any fare difference. Through fares to the Sister Islands are available for an additional US$62.20 per roundtrip. In case of no show, ticket has no value.